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Subretinal Transplantation af humane embryonale stamceller afledt retinal Pigment epitel celler ind i en stor-eyed Model af geografisk atrofi
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Biologia
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JoVE Journal Biologia
Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation af humane embryonale stamceller afledt retinal Pigment epitel celler ind i en stor-eyed Model af geografisk atrofi

DOI:
10.3791/56702-v

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11:03 min

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January 22, 2018

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, , , , ,
1Clinical Neuroscience, Section for Ophtalmology and Vision,Karolinska Institutet, 2Clinical Sciences, Intervention and Technology, Division of Obstetrics and Gynecology,Karolinska Institutet

Capítulos

  • 00:05Título
  • 01:12Subretinal Injection of Sodium Iodate into a Large-eyed Animal Model
  • 04:36Subretinal Transplantation of hESC-RPE Cells in Treated Animals
  • 07:35In Vivo Retinal and Subretinal Imaging
  • 08:47Results: Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells
  • 10:22Conclusion

Summary

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Tadução automática

Retinale pigment epitel celler kunne fungere som en celle-substitutionsterapi for avancerede form af tørre aldersrelateret makuladegeneration. Denne protokol beskriver generation af en stor-eyed model af geografisk atrofi og subretinal transplantation af humane embryonale stamceller-afledt retinale pigment epitel celler ind i denne model af sygdom.

Tags

Subretinal TransplantationHuman Embryonic Stem CellRetinal Pigment Epithelial CellsLarge-eyed Animal ModelGeographic AtrophyRegenerative MedicineAge-related Macular DegenerationOptical Coherence TomographyMicrosurgeryPars Plana TechniqueVitrectomySubretinal Injection

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