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颈动脉介入移植中颈静脉持久性转基因表达的家兔模型

JoVE Journal
Medicina

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JoVE Journal Medicina

A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts

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颈动脉介入移植中颈静脉持久性转基因表达的家兔模型

DOI:

10.3791/57231-v

•

13:58 min

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September 10, 2018

•

Lianxiang Bi*¹, Bradley K. Wacker*¹, David A. Dichek

¹Department of Medicine,University of Washington School of Medicine

Capítulos

00:04Título
00:37Vein Graft Surgery
06:57Gene Transfer Surgery after Graft Placement
11:09Vein Graft Harvest Surgery
12:05Results: High-level β-galactosidase Expression in Jugular Vein to Common Carotid Artery Interposition Grafts
13:09Conclusion

Summary

Tadução automática

该方法描述了介入静脉移植在家兔中的位置、移植物的转导以及持久性转基因表达的实现。这允许调查转基因及其蛋白产品在接枝静脉中的生理和病理作用, 以及对静脉移植病基因治疗的检测。

Tags

Keywords: Rabbit Model Transgene Expression Vein Graft Common Carotid Artery Graft Failure Vein Graft Endothelium Surgical Protocol Dissection Ligation Arteriotomy Vein Grafting

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