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利用光致硫醇-烯/yne Hydrothiolation 构造硫醚类/乙烯基硫化物栓系螺旋肽

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Química

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JoVE Journal Química

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

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利用光致硫醇-烯/yne Hydrothiolation 构造硫醚类/乙烯基硫化物栓系螺旋肽

DOI:

10.3791/57356-v

•

11:09 min

•

August 01, 2018

•

Xiaodong Shi*¹, Yinghuan Liu*¹, Rongtong Zhao, Zigang Li

¹Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School

Capítulos

00:04Título
00:38Manual Solid-Phase Peptide Synthesis
02:42Formation of Thioether Linker by On-Resin Cyclization
05:29Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization
07:02Solution-Phase Formation of a Vinyl Sulfide Linker
08:41Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides
10:42Conclusion

Summary

Tadução automática

本文提出了一种利用光致硫醇烯/硫醇-yne hydrothiolation 构建硫醚类/乙烯基硫化物栓系螺旋肽的协议。

Tags

Thioether Vinyl Sulfide Helical Peptides Photo-induced Thiol-ene/yne Hydro-thiolation Rink Amide MBHA Resin Fmoc Deprotection HCTU DIPEA Trityl Deprotection Solid-phase Peptide Synthesis

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