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Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
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JoVE Journal Medicina
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

DOI:
10.3791/57398-v

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06:57 min

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March 08, 2018

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, , , ,
1Department of Clinical Neuroscience, Section of Eye and Vision, St Erik Eye Hospital,Karolinska Institutet

Capítulos

  • 00:05Título
  • 01:06Uveal Puncture Procedure
  • 03:04Iris Dissection Procedure Under Stereoscope
  • 05:11Results: Vascular Response After Uveal Puncture
  • 06:07Conclusion

Summary

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Iris neovascularization, a common complication of ischemic retinal disease, may lead to sight-threatening neovascular glaucoma. Here, we describe a murine protocol for inducing experimental iris neovascularization that may be used for noninvasive evaluation of angiogenesis-modulating substances.

Tags

Keywords: Iris NeovascularizationMouse ModelRubeosis IridisAngiogenesisOcular Neovascular DiseaseBALB/c MiceUveal PunctureCorneal LimbusOra SerrataTraumatic CataractEnucleationFixative SolutionPBS

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