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Retroductal 纳米微粒注射液对小鼠颌下腺的治疗

JoVE Journal
Bioengenharia

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JoVE Journal Bioengenharia

Retroductal Nanoparticle Injection to the Murine Submandibular Gland

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Retroductal 纳米微粒注射液对小鼠颌下腺的治疗

DOI:

10.3791/57521-v

•

07:45 min

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May 03, 2018

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Jomy J. Varghese, Isaac L. Schmale, Yuchen Wang, Mollie Eva Hansen, Shawn D. Newlands, Catherine E. Ovitt, Danielle S. W. Benoit

¹Department of Biomedical Engineering,University of Rochester, ²Department of Otolaryngology Head and Neck Surgery,University of Rochester Medical Center, ³Center for Oral Biology,University of Rochester Medical Center

Capítulos

00:05Título
00:44Experimental Preparation
01:40Accessing and Visualizing Ductal Entry Point
02:39Ductal Cannulation and Line Placement
05:04Injection
05:52Results: Confirmation of Retroductal Nanoparticle Persistence 24 Hours Post Injection
06:50Conclusion

Summary

Tadução automática

局部药物向颌下腺的传递对了解涎腺生物学和新疗法的发展有很浓厚的兴趣。我们提出了一个更新和详细的 retroductal 注射协议, 旨在提高交付准确性和实验再现性。本文提出的应用是高分子纳米粒子的传递。

Tags

Nanoparticle Injection Submandibular Gland Retroductal Administration Murine Model Salivary Gland Dysfunction Radiation Therapy Hamilton Syringe Cannulation Atropine Dissecting Microscope Tongue Manipulation Ductal Access

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