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Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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JoVE Journal Medicina
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

DOI:
10.3791/57617-v

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06:40 min

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May 22, 2018

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, , , , , , , , ,
1Department of Cardiology-Electrophysiology, cNEP (cardiac Neuro- and Electrophysiology research group), University Heart Center,University Hospital Hamburg-Eppendorf, 2DZHK (German Center for Cardiovascular Research), 3Institute of Experimental Cardiovascular Research,University Medical Center Hamburg-Eppendorf

Capítulos

  • 00:04Título
  • 00:47Preparation of Langendorff Apparatus & Heart
  • 02:21Electrophysiological Parameters and Arrhythmogenesis
  • 03:16Förster Resonance Energy Transfer (FRET)-based Cyclic Adenosine Monophosphate (cAMP) Imaging
  • 04:51Results: The Langendorff Ex Vivo Heart Perfusion System is Useful to Study the Impact of Intracardiac Electrophysiology and Arrhythmogenesis
  • 06:07Conclusion

Summary

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Tadução automática

Here, we present a protocol for the modulation of the intracardiac autonomic nervous system and the assessment of its influence on basic electrophysiology, arrhythmogenesis, and cAMP dynamics using an ex vivo Langendorff setup.

Tags

Keywords: Intracardiac NeuronsCardiac ElectrophysiologyArrhythmogenesisLangendorff SystemAutonomic Nervous SystemCAMP DynamicsElectrophysiology CatheterProgrammed StimulationVentricular ArrhythmogenesisMulti-electrode Array

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