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1Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,University Hospital Tübingen, 2Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich,University Tübingen, 3German Center for Diabetes Research (DZD),University Tübingen
Capítulos
- 00:04Título
- 00:54Inducing Experimental Nephrotic Syndrome with Doxorubicin
- 02:24Implantation of Sustained-Release Pellets Containing Aprotinin
- 04:01Assessing Urine Serine Protease Activity
- 05:32Results: Analysis of Doxorubicin-induced Nephrotic Syndrome
- 06:48Conclusion
Here, we describe the induction of experimental nephrotic syndrome in 129S1/SvImJ mice by rapid retrobulbar injection of doxorubicin. We also treat nephrotic mice with sustained release pellets containing aprotinin to inhibit urinary serine protease activity and prevent sodium retention.
