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Bioprintable calciumalginat/gelatine Hydrogel 3D In Vitro modelsystemer fremkalde celle klumpformet dannelse
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1Department of Mechanical Engineering,McGill University Montreal, 2Department of Bioengineering,McGill University Montreal, 3Department of Molecular Biology,Instituto Potosino de Investigación Científica y Tecnológica, A.C. (IPICyT), 4Department of Mining and Materials Engineering,McGill University Montreal, 5Department of Biomedical Engineering,McGill University Montreal
Capítulos
- 00:04Título
- 00:55Preparation of the A3G7 Hydrogel Precursor
- 02:49General Testing Protocol
- 04:15Measurements of Rheological Properties of Hydrogels
- 08:15Creating a Cell-laden A3 G7 Hydrogel Precursor
- 11:143D Printing Models
- 12:52Results: Cell Spheroid Formation Induced by 3D Bioprintable Hydrogel Systems
- 14:50Conclusion
Vi udviklede en heterogen bryst kræft model bestående af udødeliggjort tumor og fibroblast celler indlejret i en bioprintable calciumalginat/gelatine bioink. Modellen sammenfatter i vivo tumor mikromiljø og letter dannelsen af flercellede tumor spheroids, giver indsigt i de mekanismer, der driver tumordannelse.
