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Nanosensors om te detecteren Protease activiteit In Vivo Noninvasive Diagnostics
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1Wallace H. Coulter Department of Biomedical Engineering,Georgia Tech College of Engineering and Emory School of Medicine, 2Parker H. Petit Institute of Bioengineering and Bioscience, 3Institute for Electronics and Nanotechnology,Georgia Tech, 4Integrated Cancer Research Center,Georgia Tech, 5The Georgia Immunoengineering Consortium,Emory University and Georgia Tech
Capítulos
- 00:04Título
- 00:36Iron Oxide Nanoparticle (IONP) Synthesis
- 05:22Peptide Design, Conjugation to Iron Oxide Nanoparticles, and In Vitro Validation
- 07:10Administration of Nanosensors and Urine Detection of Cancer
- 08:18Results: Detecting Protease Activity
- 09:52Conclusion
Proteasen zijn strak gereguleerde enzymen die betrokken zijn bij de fundamentele biologische processen en dysregulated protease-activiteit stations progressie van complexe ziekten zoals kanker. Doel van deze methode is het creëren van nanosensors die door het produceren van een decollete-signaal dat is aantoonbaar uit host urine en discrimineert ziekte protease activiteit in vivo meten.
