Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Richard Novak; Meredyth Didier; Elizabeth Calamari; Carlos F Ng; Youngjae Choe; Susan L Clauson; Bret A Nestor; Jefferson Puerta; Rachel Fleming; Sasan J Firoozinezhad; Donald E Ingber

doi:10.3791/58151

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Bioengenharia

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Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

JoVE Journal
Bioengenharia
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JoVE Journal Bioengenharia

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

DOI:

10.3791/58151-v

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14:44 min

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October 20, 2018

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Richard Novak*¹, Meredyth Didier*^1,2, Elizabeth Calamari, Carlos F Ng, Youngjae Choe, Susan L Clauson, Bret A Nestor, Jefferson Puerta, Rachel Fleming, Sasan J Firoozinezhad, Donald E Ingber^3,4

¹Wyss Institute for Biologically Inspired Engineering,Harvard University, ²Apple, Inc, ³Harvard John A. Paulson School of Engineering and Applied Sciences,Harvard University, ⁴Vascular Biology Program and Department of Surgery,Boston Children’s Hospital and Harvard Medical School

Capítulos

00:00Título
01:20Top Channel Preparation
03:55Bottom Channel Preparation
05:50PDMS Membrane Preparation
09:27Top Assembly and Preparation
11:02Chip Assembly
11:56Results and Referenced Figures
14:25Conclusion

Summary

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Here, we present a protocol that describes the fabrication of stretchable, dual channel, organ chip microfluidic cell culture devices for recapitulating organ-level functionality in vitro.

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

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