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Immunology and Infection

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JoVE Journal Immunology and Infection
Humanized hilsen/SCID/IL2rγnull (hu-NSG) mus modell for HIV replikering og ventetid studier
 
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Humanized hilsen/SCID/IL2rγnull (hu-NSG) mus modell for HIV replikering og ventetid studier

Article DOI: 10.3791/58255-v • 07:10 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1,2, 1, 1
1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope

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Denne protokollen gir en metode for å etablere humanized mus (hu-NSG) via intrahepatic injeksjon for menneskelige blodkreft stamceller i stråling-conditioned neonatal NSG mus. Hu-NSG musen er utsatt for HIV-smitte og kombinasjon antiretroviral terapi (handlevogn) og fungerer som en egnet patofysiologiske modell for HIV replikering og ventetid undersøkelser.

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Immunologi og infeksjon problemet 143 Neonatal NSG mus Humanized mus HSCs HIV handlevogn ventetid
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