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载脂蛋白 E 缺乏小鼠盐皮质激素受体的活化诱导动脉粥样硬化斑块的研究

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Medicina

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JoVE Journal Medicina

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

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载脂蛋白 E 缺乏小鼠盐皮质激素受体的活化诱导动脉粥样硬化斑块的研究

DOI:

10.3791/58303-v

•

07:36 min

•

September 26, 2018

•

Vincenzo Marzolla, Andrea Armani, Caterina Mammi, Alessandra Feraco, Massimiliano Caprio²

¹Laboratory of Cardiovascular Endocrinology,IRCCS San Raffaele Pisana, Rome, Italy, ²Department of Human Sciences and Promotion of the Quality of Life,San Raffaele Roma Open University, Rome, Italy

Capítulos

00:04Título
00:45Osmotic Pump Filling and Implantation
02:38Heart Dissection
04:03Aortic Root Sectioning and Oil Red O Neutral Fat Staining
05:47Results: Evaluation of the Aortic Root Phenotype in Aldosterone-induced Atherosclerosis in Apolipoprotein-E Knockout (ApoE ^-/-) Mice
06:28Conclusion

Summary

Tadução automática

我们描述了一种通过连续释放醛固酮来诱导动脉粥样硬化饮食喂养的鼠主动脉根部动脉粥样硬化的协议。还介绍了斑块组成的表征方法。

Tags

Keywords: Atherosclerosis Apolipoprotein E-deficient Mice Mineralocorticoid Receptors Aldosterone Mini-pump Implantation Atherosclerotic Plaque Induction Perfusion

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