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吸入麻醉下鼻内给药评价鼻腔给脑药物的新方法

JoVE Journal
Medicina

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JoVE Journal Medicina

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

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吸入麻醉下鼻内给药评价鼻腔给脑药物的新方法

DOI:

10.3791/58485-v

•

05:44 min

•

November 14, 2018

•

Takanori Kanazawa*¹, Mitsuyoshi Fukuda*¹, Naoto Suzuki, Toyofumi Suzuki

¹Laboratory of Pharmaceutics, School of Pharmacy,Nihon University

Capítulos

00:04Título
01:04Intranasal Drug Administration
03:11Radio-Labeled Water-Soluble Macromolecules ([¹⁴C]-inulin) Quantification
04:32Results: Comparison of Brain [¹⁴C]-Inulin Levels After Two Different Methods of Intranasal Administration
05:17Conclusion

Summary

Tadução automática

在这里, 我们描述了两种新的方法稳定鼻内给药吸入麻醉与最小的物理压力实验动物。我们还描述了一种方法, 定量评估药物分布水平的药物分布水平通过鼻对大脑的途径使用放射性色标 [^14c]-伊努林作为水溶性大分子的模型底物。

Tags

Keywords: Intranasal Administration Nose-to-brain Drug Delivery Inhalation Anesthesia Carbon-14 Inulin Reverse Cannulation Esophageal Cannula Programmable Microsyringe Pump Blood-brain Barrier Pharmacokinetics Pharmacology Central Nervous System Diseases Drug Delivery Technologies

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