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JoVE Journal Neuroscience
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
 

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Article DOI: 10.3791/59268-v • 07:01 min • May 16th, 2019
May 16th, 2019 •
*1,5, *2,3, 1,4, 2,3, 1,5
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged
* These authors contributed equally

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Resumo
Automatic Translation

The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.

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Keywords: Electrophoretic Delivery GABA Epileptic Focus Seizure Prevention Microaerophilic Ion Pump Drug Delivery Neurological Diseases Stereotaxic Frame Silicon Probe Hippocampus
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