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Immunology and Infection

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JoVE Journal Immunology and Infection
Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker
 

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker

Article DOI: 10.3791/59373-v • 11:28 min • May 31st, 2019
May 31st, 2019 •
1, 1, 1, 1, 1, 2, 2, 1
1US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 2IDT Biologika GmbH, Am Pharmapark

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We offered captive mongooses placebo oral rabies vaccine baits with ethyl or methyl iophenoxic acid as a biomarker and verified bait uptake using a novel liquid chromatography with tandem mass spectrometry (LC-MS/MS) method.

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Keywords: Iophenoxic Acid Mongoose Serum Biological Marker Oral Rabies Vaccination Protein Precipitation Methyl-IPA Ethyl-IPA Analytical Method HPLC Quantification Parts Per Billion
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