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改良异位异体下肢骨皮瓣模型在大鼠转化血管化复合同种异体移植研究中的应用

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Medicina

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JoVE Journal Medicina

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

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改良异位异体下肢骨皮瓣模型在大鼠转化血管化复合同种异体移植研究中的应用

DOI:

10.3791/59458-v

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09:36 min

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April 26, 2019

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Yoram Fleissig, Robert M. Reed³, Jason E. Beare³, Amanda J. LeBlanc⁴, Stuart K. Williams⁴, Christina L. Kaufman, James B. Hoying⁴

¹Christine M. Kleinert Institute for Hand and Microsurgery, ²Cardiovascular Innovation Institute,University of Louisville, ³Kentucky Spinal Cord Injury Research Center,University of Louisville, ⁴Department of Physiology,University of Louisville

Capítulos

00:04Título
01:05Procedure Overview
02:03Donor Allograft Harvest
05:16Recipient Transplantation Surgery
07:26Results: Histopathological Follow-up and Analysis After Vascularized Composite Allotransplantation (VCA)
09:05Conclusion

Summary

Tadução automática

血管化复合同种异体移植为移植受者提供了改变生活的益处, 但移植排斥反应和血管病变的生物学原因仍然鲜为人知。这里介绍的啮齿类动物手术模型提供了一个可重复的, 临床相关的移植模型, 使研究人员能够评估排斥事件和潜在的治疗策略, 以防止其发生。

Tags

Keywords: Vascularized Composite Allotransplantation Hindlimb Osteomyocutaneous Flap Rat Model Vasculopathy Graft Rejection Macrovascular Surgical Techniques Ischemic Damage Skin Muscle Bone Orthotopic Models Hand Transplant Donor Vessels Recipient Surgical Site Inguinal Pocket

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