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Journal / Bioengineering / Human Neural Organoids for Studying Brain Cancer…
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Bioengineering

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JoVE Journal Bioengineering
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
 

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Article DOI: 10.3791/59682-v • 09:36 min • June 28th, 2019
June 28th, 2019 •
*1, *2, 2, 3, 3, 4, 5, 4, 2
1Laboratory of Tumor Immunology, Translational Research Center in Onco-Hematology, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, 2Department of Pathology and Immunology, University Medical Center, University of Geneva, 3Laboratory of Toxicology and Therapeutic Drug Monitoring, Geneva University Hospitals, 4Tissue Engineering Laboratory, Hepia/HES-SO, University of Applied Sciences Western Switzerland, 5Laboratory of Experimental cell therapy, Department of Diagnostics, Geneva University Hospitals
* These authors contributed equally

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This study introduces and describes protocols to derive two specific human neural organoids as a relevant and accurate model for studying 1) human glioblastoma development within human neural organoids exclusively in humans and 2) neuron dopaminergic differentiation generating a three-dimensional organoid.

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Keywords: Neural Organoids Brain Cancer Neurodegenerative Diseases Pluripotent Stem Cells Three-dimensional Culture Neurosphere Neural Induction ROCK Inhibitor Dual-SMAD Inhibition Glioblastoma Parkinson's Disease Regenerative Medicine Physiological Development Reproducibility
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