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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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JoVE Journal Química
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

DOI:
10.3791/60184-v

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08:59 min

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December 03, 2020

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, , , , , , , , ,
1Brazilian Biosciences National Laboratory (LNBio),Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS),Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology,University of Campinas

Summary

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Tadução automática

We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

Tags

Microphysiological SystemPharmacokinetic AssessmentToxicological AssessmentIntestineLiverDrug TestingIn VitroOrgan-on-a-chipAcetaminophenHPLC AnalysisCell Viability

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