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大鼠中枢神经系统中反义寡核苷酸的细胞内传递

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

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大鼠中枢神经系统中反义寡核苷酸的细胞内传递

DOI:

10.3791/60274-v

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07:47 min

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October 29, 2019

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Capítulos

00:04Título
00:46Material and Instrument Preparation
02:09Surgery Preparation
03:05Surgery
06:53Results: A Single Bolus Antisense Oligonucleotide (ASO) Intrathecal Injection Reduces Rat Malat1 In Vivo
07:17Conclusion

Summary

Tadução automática

在这里，我们描述了一种通过将导管植入脊柱的腰间空间来向大鼠中枢神经系统输送药物的方法。我们专注于反义寡核苷酸的输送，尽管这种方法也适合其他治疗方式的交付。

Tags

Intrathecal Delivery Antisense Oligonucleotides Rat Central Nervous System Pharmacokinetics Pharmacodynamics Efficacy Guide Cannula Catheter Wire Assembly Delivery Catheter Assembly Guide Cannula-needle Assembly Spinal Cord Injection Buprenorphine Surgical Procedure

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