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1Department of Pharmacology and Toxicology,University of Louisville, 2Hepatobiology and Toxicology Program,University of Louisville, 3Department of Physiology and Pharmacology,West Virginia University, 4Center for Inhalation Toxicology,West Virginia University, 5Department of Pharmacology and Chemical Biology,University of Pittsburgh, 6Pittsburgh Liver Research Center,University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition,University of Pittsburgh
Capítulos
- 00:04Título
- 00:42Experimental Setup and Purified Experimental Diet Acclimatization
- 01:21Vinyl Chloride (VC) Inhalation Exposure System Setup
- 02:17Pre-Exposure Setup
- 03:21Exposure Experiment and VC Concentration Validation
- 06:12Post-Exposure
- 07:01Results: Representative Effects of VC on the Enhancement of Diet-Induced Liver Injury
- 08:29Conclusion
O objetivo deste protocolo era desenvolver um modelo do murine da exposição low-level do toxicant que não causa ferimento evidente do fígado mas agrava um pouco dano preexistente do fígado. Este paradigma melhor recapitula a exposição humana e as mudanças sutis que ocorrem após a exposição a concentrações tóxicas que são consideradas seguras.
