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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
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JoVE Journal Medicina
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

DOI:
10.3791/60409-v

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09:03 min

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November 15, 2019

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, , , , , , ,
1Department of Ophthalmology,Stanford University School of Medicine, 2Department of Ophthalmology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, 3Department of Ophthalmology,Second Xiangya Hospital of Central South University, 4Department of Ophthalmology,Veterans Affairs Palo Alto Health Care

Capítulos

  • 00:04Título
  • 01:24Ocular Hypertension Induction by Intracameral Injection of Silicone Oil
  • 02:33Intracameral Silicon Oil Injection for One Eye
  • 04:30Silicone Oil Removal
  • 05:59IOP (Intraocular Pressure) Measurement Once a Week
  • 07:02Results: Quantification of Silicon Oil-Induced Ocular Hypertension and Degeneration in Mice
  • 08:19Conclusion

Summary

Tadução automática

Tadução automática

Here, we present a protocol to induce ocular hypertension and glaucomatous neurodegeneration in mouse eyes by intracameral injection of silicone oil and the procedure for silicone oil removal from the anterior chamber to return elevated intraocular pressure to normal.

Tags

Ocular HypertensionGlaucomaMouse ModelSilicone OilIntraocular PressureRetinal Ganglion CellNeurodegenerationNeuroprotectionCorneal EntryIntracameral Injection

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