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1Sheikh Zayed Institute for Pediatric Surgical Innovation,Children’s National Hospital, 2Children’s National Heart Institute,Children’s National Hospital, 3Center for Neuroscience Research,Children’s National Hospital, 4Department of Biomedical Engineering, School of Engineering,University of Alabama at Birmingham, 5Department of Pediatrics, Department of Pharmacology & Physiology, School of Medicine and Health Sciences,George Washington University
Capítulos
- 00:05Título
- 01:02Heart Excision and Langendorff Perfusion
- 02:42Electrophysiology Study
- 05:17Transmembrane Voltage and Intracellular Calcium Optical Mapping
- 06:55Cleanup
- 07:20Results: Representative Optical Data from Langendorff-Perfused Model Hearts
- 08:59Conclusion
L'obiettivo di questo studio era quello di stabilire un metodo per studiare le dinamiche cardiache utilizzando un modello animale traslazionale. L'approccio sperimentale descritto incorpora l'optocardiografia a doppia emissione in combinazione con uno studio elettrofisiologico per valutare l'attività elettrica in un modello cardiaco porcina isolato e intatto.
