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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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Medicina
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JoVE Journal Medicina
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

DOI:
10.3791/60954-v

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07:13 min

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April 30, 2020

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, ,
1Department of Medicine/Heart and Vascular Institute,Tulane University, 2Department of Physiology,Tulane University, 3Department of Pharmacology,Tulane University

Capítulos

  • 00:04Introduction
  • 00:38Surgical Ascending Aortic Banding (AAB) Procedure Preparation
  • 01:48AAB Procedure
  • 03:10Echocardiography
  • 04:18Results: Representative Pressure Overload-Induced Remodeling and Systolic Dysfunction Analyses
  • 06:37Conclusion

Summary

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We describe the creation of a rat model of pressure overload induced moderate remodeling and early systolic dysfunction where signal transduction pathways involved in the initiation of the remodeling process are activated. This animal model will aid in identifying molecular targets for applying early therapeutic anti-remodeling strategies for heart failure.

Tags

Keywords: Rat ModelPressure OverloadCardiac RemodelingSystolic DysfunctionHeart FailureMetabolic RemodelingMyocardial DysfunctionCalcium CyclingVascular ClipThoracotomyEchocardiographic Imaging

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