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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
JoVE Journal
Medicina
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JoVE Journal Medicina
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

DOI:
10.3791/61088-v

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08:21 min

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June 15, 2020

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, , ,
1Department of Medicine,Queen’s University

Capítulos

  • 00:04Introduction
  • 00:37Right Carotid and Jugular Isolation
  • 02:34Right Ventricular Catheterization
  • 04:32Left Ventricular Catheterization
  • 06:21Results: PV Loop Analyses and Hemodynamic Parameter Measurements
  • 07:42Conclusion

Summary

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Tadução automática

Presented here is a protocol to assess biventricular heart function in mice by generating pressure-volume (PV) loops from the right and left ventricle in the same animal using closed chest catheterization. The focus is on the technical aspect of surgery and data acquisition.

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Keywords: Biventricular AssessmentCardiac FunctionPressure-volume LoopsClosed-chest CatheterizationMiceRight Carotid ArteryRight Jugular VeinRight Ventricle CatheterizationLeft VentricleSystolic FunctionDiastolic FunctionPressure WaveformCardiac Characterization

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