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建模年龄相关的神经退行性疾病在 卡诺哈布迪蒂斯埃利根
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Biologia
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JoVE Journal Biologia
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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建模年龄相关的神经退行性疾病在 卡诺哈布迪蒂斯埃利根

DOI:
10.3791/61169-v

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07:04 min

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August 15, 2020

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,
1Institute of Molecular Biology and Biotechnology,Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine,University of Crete, Heraklion, 70013, Crete, Greece

Capítulos

  • 00:00Introduction
  • 00:39Necrotic Cell Death-induced by Hyperactive Ion Channels
  • 04:06Protein Aggregate-induced Neurodegeneration
  • 05:58Representative Results: Monitor Necrotic Cell Death-Induced by Hyperactive Ion Channels and Protein Aggregate-induced Neurodegeneration
  • 06:30Conclusion

Summary

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Tadução automática

在这里，我们介绍和描述广泛的方法，利用一些多功能线虫模型，包括高活性离子通道诱导坏死和蛋白质聚合诱导神经毒性，以监测和解剖年龄相关的神经退行性疾病的细胞和分子基础。

Tags

Keywords: Caenorhabditis ElegansNeurodegenerative DiseasesAlzheimer’sParkinson’sHuntington’s DiseaseProtein AggregatesNeurotoxicityNecrosisNematode CultureHeat ShockL1 LarvaeMicroscopyNeurodegeneration

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