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1The Graduate Program for Neuroscience,Boston University, 2Department of Biology,Boston University, 3Neurophotonics Center,Boston University, 4Center for Systems Neuroscience,Boston University, 5Research and Early Development,Biogen, 6Department Pharmacology and Experimental Therapeutics,Boston University
Capítulos
- 00:04Introduction
- 01:08Preparation for Surgery
- 02:24In Utero Electroporation Surgery
- 04:51Results: Social Behavior in Juvenile and Adult Mice
- 06:34Conclusion
De rol van recent ontdekte ziekte-geassocieerde genen in de pathogenese van neuropsychiatrische aandoeningen blijft onduidelijk. Een gemodificeerde bilaterale in utero elektroporatie techniek maakt de genoverdracht in grote populaties neuronen en onderzoek van de veroorzakers van genexpressie veranderingen op sociaal gedrag mogelijk.
Tags
Bilateral In Utero ElectroporationGenetic InfluencesRodent BehaviorGene ExpressionNeurological DiseasesGenetic Animal LinesNeurological DisordersGene TransferPathologyNovel TherapiesEmbryo ManipulationGene TransferPregnant DamSurgerySterileDNA SolutionGlass PipetteAnesthesiaAnalgesiaAbdominal Incision
