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近红外光免疫疗法为小鼠模型的胸膜传播
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JoVE Journal Medicina
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
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近红外光免疫疗法为小鼠模型的胸膜传播

DOI:
10.3791/61593-v

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05:39 min

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February 09, 2021

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, , , , ,
1Respiratory Medicine,Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU),Nagoya University Institute for Advanced Research

Capítulos

  • 00:05Introduction
  • 00:31Pleural Dissemination Model Generation
  • 01:44Bioluminescence (BLI) Measurement
  • 03:02Near-Infrared Photoimmunotherapy (NIR-PIT)
  • 04:08Results: Representative NIR-PIT Thoracic Mouse Tumor Treatment
  • 05:13Conclusion

Summary

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Tadução automática

近红外光免疫疗法（NIR-PIT）是一种新兴的癌症治疗策略，利用抗体光吸收剂（IR700Dye）结合光和NIR光来破坏癌细胞。在这里，我们提出了一种方法，评估NIR-PIT的抗肿瘤作用，在小鼠模型的胸膜传播肺癌和恶性胸膜间皮瘤使用生物发光成像。

Tags

Keywords: Near Infrared PhotoimmunotherapyPleural DisseminationMouse ModelBioluminescence ImagingD-luciferin690-nanometer LaserLight Dose

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