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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
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JoVE Journal Medicina
A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

DOI:
10.3791/61865-v

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05:20 min

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November 12, 2020

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, , , , , ,
1Laboratory of Photobiology,Keio University School of Medicine, 2Department of Ophthalmology,Keio University School of Medicine, 3Animal eye care,Tokyo Animal Eye Clinic, 4Tsubota Laboratory, Inc.

Capítulos

  • 00:04Introduction
  • 01:00Transient Bilateral Common Carotid Artery Occlusion (tBCCAO)
  • 03:12Results: Analysis of Eyelid Drooping, HIF-1α Stabilization, Reactive Gliosis, Visual Dysfunction, and Change in Retinal Thickness After tBCCAO
  • 04:40Conclusion

Summary

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Here, we describe a mouse model of retinal ischemia by transient bilateral common carotid artery occlusion using simple sutures and a clamp. This model can be useful for understanding the pathological mechanisms of retinal ischemia caused by cardiovascular abnormalities.

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Keywords: Ischemic Retinal InjuryTransient Bilateral Common Carotid Artery OcclusionMurine ModelRetinal IschemiaPathophysiologyIschemic RetinopathiesIn Vivo Drug ScreeningVascular DiseasesDiabetic RetinopathyOcclusion Of Retinal Veins Or ArteriesOcular Ischemic SyndromeBALB/c MiceEyelid Drooping

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