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由瞬态双边常见胡萝卜动脉闭塞引起的缺血性视网膜损伤的 Murine 模型

JoVE Journal
Medicina

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JoVE Journal Medicina

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

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由瞬态双边常见胡萝卜动脉闭塞引起的缺血性视网膜损伤的 Murine 模型

DOI:

10.3791/61865-v

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05:20 min

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November 12, 2020

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Deokho Lee*^1,2, Yukihiro Miwa*^1,2,3, Heonuk Jeong², Shin-ichi Ikeda², Yusaku Katada², Kazuo Tsubota^2,4, Toshihide Kurihara²

¹Laboratory of Photobiology,Keio University School of Medicine, ²Department of Ophthalmology,Keio University School of Medicine, ³Animal eye care,Tokyo Animal Eye Clinic, ⁴Tsubota Laboratory, Inc.

Capítulos

00:04Introduction
01:00Transient Bilateral Common Carotid Artery Occlusion (tBCCAO)
03:12Results: Analysis of Eyelid Drooping, HIF-1α Stabilization, Reactive Gliosis, Visual Dysfunction, and Change in Retinal Thickness After tBCCAO
04:40Conclusion

Summary

Tadução automática

在这里，我们描述了一个鼠标模型的视网膜缺血通过瞬态的双边常见的胡萝卜动脉闭塞使用简单的缝合线和夹子。该模型可用于了解心血管异常引起的视网膜缺血的病理机制。

Tags

Keywords: Ischemic Retinal Injury Transient Bilateral Common Carotid Artery Occlusion Murine Model Retinal Ischemia Pathophysiology Ischemic Retinopathies In Vivo Drug Screening Vascular Diseases Diabetic Retinopathy Occlusion Of Retinal Veins Or Arteries Ocular Ischemic Syndrome BALB/c Mice Eyelid Drooping

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