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通过压力-体积环路分析确定心脏对β肾上腺素能刺激的反应

JoVE Journal
Medicina

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JoVE Journal Medicina

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

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通过压力-体积环路分析确定心脏对β肾上腺素能刺激的反应

DOI:

10.3791/62057-v

•

08:05 min

•

May 19, 2021

•

Rebekka Medert*^1,2, Lucas Bacmeister*^1,2,3, Sebastian Segin*^1,2,4, Marc Freichel², Juan E. Camacho Londoño²

¹Pharmakologisches Institut,Ruprecht-Karls-Universität Heidelberg, ²DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, ³Department of Internal Medicine III,University of Heidelberg, ⁴Department of Anesthesiology,University Hospital RWTH Aachen

Capítulos

00:04Introduction
00:42Femoral Cannulation
01:51Thoracotomy
02:58Pressure Volume Loop (PVL) Measurement
04:15PVL Parallel-Conductance Calibration
04:54PVL Conductance-to-Volume Calibration
05:32Results: Representative PVL Analysis
07:11Conclusion

Summary

Tadução automática

在这里，我们描述了在增加静脉输注的异丙肾上腺素剂量下的心脏压力 - 体积环路分析，以确定小鼠的内在心脏功能和β肾上腺素能储备。我们使用改进的开胸方法进行压力 - 体积回路测量，其中我们包括具有正呼气末压的通气。

Tags

Cardiac Response Î²-adrenergic Stimulation Pressure-volume Loop Analysis Open-chest Approach Positive End-expiratory Pressure Load-independent Cardiac Function Î²-adrenergic Reserve Femoral Vein Cardiac Apex Pressure-volume Catheter Cardiac Function Parameters

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