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Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
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Neurociência
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JoVE Journal Neurociência
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

DOI:
10.3791/62094-v

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08:40 min

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February 28, 2021

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, , , , ,
1Laboratory of Nuclear Medicine (LIM-43), Departamento de Radiologia e Oncologia, Faculdade de Medicina,Universidade de Sao Paulo, 2Nuclear Medicine Division,Hospital Sirio-Libanes

Capítulos

  • 00:00Introduction
  • 00:33Lysolecithin Solution Preparation
  • 01:10Lysolecithin Rat Model Stereotaxic Surgery
  • 03:01PET Acquisition
  • 04:47Image Analysis
  • 07:41Representative Results
  • 07:53Conclusion

Summary

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This protocol has the aim of monitoring in vivo myelin changes (demyelination and remyelination) by positron emission tomography (PET) imaging in an animal model of multiple sclerosis.

Tags

Positron Emission TomographyPET ImagingMyelinLysolecithinMultiple SclerosisRat ModelStereotactic InjectionPIB TracerPET ScanIn Vivo ImagingTracer Injection

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