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植入遥测心电图和血压递质组合以确定意识小鼠的自发压力反射敏感性

JoVE Journal
Medicina

This content is Free Access.

JoVE Journal Medicina

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

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植入遥测心电图和血压递质组合以确定意识小鼠的自发压力反射敏感性

DOI:

10.3791/62101-v

•

09:56 min

•

February 14, 2021

•

René D. Rötzer, Verena F. Brox, Konstantin Hennis, Stefan B. Thalhammer, Martin Biel², Christian Wahl-Schott, Stefanie Fenske²

¹Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy,Ludwig-Maximilians-Universität München, ²German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, ³Hannover Medical School,Institute for Neurophysiology

Capítulos

00:05Introduction
01:34Dissection of the Left Common Carotid
04:09Cannulation of the Left Common Carotid Artery
05:11Placement of the Telemetry Device Body and ECG Leads
07:29Results: Analysis of BRS Using the Sequence Method on Simultaneous Telemetric ECG and BP Recordings
08:58Conclusion

Summary

Tadução automática

压力反射是自主神经系统响应血压变化的心率调节机制。我们描述了一种植入遥测发射器的手术技术，用于连续和同时测量小鼠的心电图和血压。这可以确定自发性压力反射敏感性，这是心血管疾病的重要预后标志物。

Tags

Keywords: Telemetry ECG Blood Pressure Baroreflex Sensitivity Conscious Mice Cardiovascular Disease Microsurgery Carotid Artery Anesthesia Depilatory Cream Skin Incision Blunt Dissection Parotid Gland Submandibular Gland Trachea

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