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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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JoVE Journal Medicina
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

DOI:
10.3791/62230-v

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09:02 min

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February 02, 2021

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, , , , , ,
1Department of Cardiac Surgery, Boston Children’s Hospital,Harvard Medical School

Capítulos

  • 00:05Introduction
  • 00:56Surgical Preparation and Vascular Access
  • 02:16Induction of Renal Ischemia-Reperfusion Injury
  • 05:37Post-Reperfusion
  • 06:37Results: Assessment of Renal Function Before and After Renal Ischemia-Reperfusion Injury
  • 08:23Conclusion

Summary

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This study presents a highly reproducible large animal model of renal ischemia-reperfusion injury in swine using temporary percutaneous bilateral balloon-catheter occlusion of the renal arteries for 60 min and reperfusion for 24 h.

Tags

Large Animal ModelAcute Kidney InjuryRenal Ischemia Reperfusion InjuryRenal Artery OcclusionPreclinical ModelRenal TransplantationRenal HypoperfusionTranscatheter ProceduresCardiovascular ProceduresCarotid ArteryJugular VeinFemoral ArteryAngiographyRenal ArteriesBalloon Catheter

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