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Multi-tidsskala mikroskopi metoder for karakterisering av fluorescerende merket mikrobobler for ultralyd-utløst legemiddel frigjøring
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1Physics of Fluids group, Department of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center,University of Twente, 2BIOS Lab-on-a-Chip group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center,University of Twente, 3Department of Biotechnology and Nanomedicine,SINTEF Industry, 4Department of Circulation and Medical Imaging,Norwegian University of Science and Technology, 5Department of Health Research,SINTEF Digital, 6Cancer Clinic,St. Olav’s Hospital, 7Department of Physics,Norwegian University of Science and Technology
Capítulos
- 00:05Introduction
- 00:45Imaging by Brightfield Microscopy
- 02:05Imaging by Fluorescence Microscopy
- 02:52Imaging Protocol by Intravital Microscopy
- 04:07Results: In Vitro and In Vivo Behavior of Insonified Microbubble
- 05:22Conclusion
De presenterte protokollene kan brukes til å karakterisere responsen til fluorescerende merkede mikrobobler designet for ultralydutløste legemiddelleveringsapplikasjoner, inkludert deres aktiveringsmekanismer så vel som deres bioeffekter. Dette papiret dekker en rekke in vitro - og in vivo-mikroskopiteknikker som utføres for å fange opp relevant lengde og tidsskalaer.
