É necessária uma assinatura da JoVE para visualizar este conteúdo. Faça login ou comece sua avaliação gratuita.
Capítulos
- 00:04Introduction
- 00:55Implanting Electroencephalogram (EEG) and Electrocardiogram (ECG) Electrodes and Attaching Respiratory Monitors
- 02:45Video EEG-ECG Recording
- 03:32Photic Stimulation
- 04:59Oral Medication Administration
- 05:52Intravenous Medication Administration
- 07:08Analysis of ECG and Video-EEG
- 08:23Results: Identification of Seizures and Arrhythmias in Conscious Restrained Rabbits
- 09:41Conclusion
Using simultaneous video-EEG-ECG-oximetry-capnography, we developed a methodology to evaluate the susceptibility of rabbit models to develop provoked arrhythmias and seizures. This novel recording system establishes a platform to test the efficacy and safety of therapeutics and can capture the complex cascade of multi-system events that culminate in sudden death.
