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1Research Group Biomedical Physics,Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department,Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology,University Medical Center Goettingen, 4Institute for Nonlinear Dynamics,Georg-August-University Goettingen, 5Department of Cardiology and Pneumology,University Medical Center Goettingen, 6German Center for Cardiovascular Research,DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit,German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK),University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools,University of Freiburg
Capítulos
- 00:04Introduction
- 00:54Langendorff Perfusion
- 02:53Arrhythmia Induction and Optical Defibrillation
- 04:41Optical Mapping
- 05:45Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation
- 07:56Conclusion
Diese Arbeit berichtet über eine Methode zur Kontrolle des Herzrhythmus intakter muriner Herzen von transgenen Kanalrhodopsin-2 (ChR2) Mäusen unter Verwendung lokaler Photostimulation mit einem Mikro-LED-Array und gleichzeitiger optischer Kartierung des Epikardialmembranpotentials.
