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Portalveneninjektion von Darmkrebs-Organoiden zur Untersuchung der Lebermetastasierung Stroma
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1Adelaide Medical School,University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology,Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer,Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine,The University of Tokyo, 6Translational and Clinical Research Institute,Newcastle University, 7International Center for Cell and Gene Therapy,Fujita Health University
Capítulos
- 00:04Introduction
- 01:18Portal Vein Injection of Colorectal Cancer Organoids
- 05:39Results: Liver Metastases, Tumor Growth Kinetics, Bone Morphogenetic Protein Signaling and Tumor Proliferation Induced by Portal Vein AAV8-Injection
- 07:29Conclusion
Portalveneninjektion von Darmkrebs (CRC) Organoiden erzeugt stromareiche Lebermetastasen. Dieses Mausmodell der CRC-Lebermetastasierung stellt ein nützliches Werkzeug dar, um Tumor-Stroma-Interaktionen zu untersuchen und neuartige Stroma-gerichtete Therapeutika wie Adeno-assoziierte virusvermittelte Gentherapien zu entwickeln.
