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Inyección en la vena porta de organoides de cáncer colorrectal para estudiar la metástasis hepática del estroma
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1Adelaide Medical School,University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology,Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer,Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine,The University of Tokyo, 6Translational and Clinical Research Institute,Newcastle University, 7International Center for Cell and Gene Therapy,Fujita Health University
Capítulos
- 00:04Introduction
- 01:18Portal Vein Injection of Colorectal Cancer Organoids
- 05:39Results: Liver Metastases, Tumor Growth Kinetics, Bone Morphogenetic Protein Signaling and Tumor Proliferation Induced by Portal Vein AAV8-Injection
- 07:29Conclusion
La inyección de organoides de cáncer colorrectal (CCR) en la vena porta genera metástasis hepáticas ricas en estroma. Este modelo de ratón de metástasis hepática del CCR representa una herramienta útil para estudiar las interacciones tumor-estroma y desarrollar nuevas terapias dirigidas al estroma, como las terapias génicas mediadas por virus adenoasociadas.
