Journal
/
Bioengenharia
/
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
JoVE Journal
Bioengenharia
É necessária uma assinatura da JoVE para visualizar este conteúdo.  Faça login ou comece sua avaliação gratuita.
JoVE Journal Bioengenharia
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

DOI:
10.3791/62694-v

•

07:02 min

•

July 15, 2021

•

, , , , , , , , , , ,
1Department of Thoracic Surgery,Vanderbilt University Medical Center, 2Department of Biomedical Engineering,Carnegie Mellon University, 3Department of Pediatrics,Columbia University Medical Center, Columbia University Irving Medical Center, 4Department of Medicine,Columbia University Medical Center, Columbia University Irving Medical Center, 5Department of Anesthesiology,Vanderbilt University Medical Center, 6Department of Biomedical Engineering,Vanderbilt University

Capítulos

  • 00:04Introduction
  • 00:52Operative Procedure
  • 05:03Chronic PA Banding (9-10 Weeks)
  • 06:07Results: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
  • 06:37Conclusion

Summary

Tadução automática

Tadução automática

This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.

Tags

Pulmonary HypertensionRight Ventricular FailureLarge Animal ModelLeft Pulmonary Artery LigationPulmonary Artery BandingRV AdaptationRV-targeted TherapeuticsSurgical ProcedureSheep ModelThoracotomyPulmonary Artery DissectionVascular OccluderRight Ventricular Pressure Line

Article

Embed

ADICIONAR À PLAYLIST

Usage Statistics

Vídeos Relacionados

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Tunable Hydrogels from Pulmonary Extracellular Matrix for 3D Cell Culture

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Read Article