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Evaluering af motorisk svækkelse i C. elegans Modeller af Amyotrofisk Lateral Sklerose
JoVE Journal
Neurociência
This content is Free Access.
JoVE Journal Neurociência
Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluering af motorisk svækkelse i C. elegans Modeller af Amyotrofisk Lateral Sklerose

DOI:
10.3791/62699-v

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08:27 min

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September 02, 2021

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,
1Geriatrics Research Education and Clinical Center,Veterans Affairs Puget Sound Health Care System, 2Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington

Capítulos

  • 00:04Introduction
  • 00:45Radial Locomotion Assay
  • 02:10Computer-Analyzed Swimming Assay
  • 05:51Data Analysis
  • 06:19Results: Analysis of the Crawling Speeds in Radial Locomotion and Thrashing in the Swimming Assay
  • 07:48Conclusion

Summary

Tadução automática

Tadução automática

Denne protokol beskriver to følsomme assays til kræsning blandt mild, moderat, og svær motorisk svækkelse i C. elegans modeller af amyotrofisk lateral sklerose, med generelle nytte for C. elegans stammer, med ændret motilitet.

Tags

C. ElegansAmyotrophic Lateral Sclerosis (ALS)Motor ImpairmentRadial Locomotion AssaySwimming AssayMotility PhenotypesMovement QuantificationComputer-based TrackingThrashing Movements

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