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研究钝力损伤对成年斑马鱼影响的可扩展模型

JoVE Journal
Neurociência

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JoVE Journal Neurociência

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

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研究钝力损伤对成年斑马鱼影响的可扩展模型

DOI:

10.3791/62709-v

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08:13 min

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May 31, 2021

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James Hentig^2,3, Kaylee Cloghessy^2,3, Chloe Dunseath³, David R. Hyde^2,3

¹Department of Biological Sciences,University of Notre Dame, ²Center for Zebrafish Research,University of Notre Dame, ³Center for Stem Cells and Regenerative Medicine,University of Notre Dame

Capítulos

00:04Introduction
00:38Traumatic Brain Injury Paradigm
02:26Brain Dissection
03:54Edema Studies in the Zebrafish Brain
04:42Labeling Cellular Proliferation Across the Neuroaxis and Preparing Fixed Tissue
05:33Results: Effects of Blunt-Force Injury in Adult Zebrafish
07:28Conclusion

Summary

Tadução automática

我们修改了成年斑马鱼的Marmarou体重下降模型，以检查钝力创伤性脑损伤（TBI）后的病理范围以及随后神经元再生的机制。这种钝力 TBI 模型具有可扩展性，可诱发轻度、中度或重度 TBI，并概括在人类 TBI 中观察到的损伤异质性。

Tags

Keywords: Zebrafish Blunt-force Injury Traumatic Brain Injury TBI Modeling Clay Steel Disc Ball Bearing Injury Severity Dissection Optic Nerve Parietal Plate

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