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A Preclinical Model of Exertional Heat Stroke in Mice
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JoVE Journal Medicina
A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

DOI:
10.3791/62738-v

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08:22 min

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July 01, 2021

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, , ,
1Department of Applied Physiology and Kinesiology, College of Health and Human Performance,University of Florida, 2Department of Nutrition and Integrative Physiology, College of Health and Human Sciences,Florida State University

Capítulos

  • 00:05Introduction
  • 00:55Surgical Implantation of the Telemetric Temperature Monitoring System
  • 02:35EHS Protocol
  • 06:43Results: Exertional Heat Stroke in Mice
  • 07:42Conclusion

Summary

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The protocol describes the development of a standardized, repeatable, preclinical model of exertional heat stroke (EHS) in mice free from adverse external stimuli such as electric shock. The model provides a platform for mechanistic, preventative, and therapeutic studies.

Tags

Keywords: Preclinical ModelExertional Heat StrokeMiceTelemetrySurgical ImplantationCore Temperature MonitoringEnvironmental ChamberAnesthesiaBuprenorphineAseptic TechniqueRecovery

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