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用于量化生长因子介导的整合素力学和附着力的张力计系绳探头
JoVE Journal
Biologia
This content is Free Access.
JoVE Journal Biologia
Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
DOI:

09:56 min

February 11, 2022

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Capítulos

  • 00:04Introduction
  • 00:47Surface Preparation
  • 04:25Cell Preparation and Staining
  • 06:28Image Acquisition
  • 07:43Results: Effect of Ligand-Activated EGFR on Integrin-Mediated Cell Mechanics and Adhesion Formation in Cos-7 Cells
  • 09:11Conclusion

Summary

Tadução automática

TGT表面是研究生长因子整合素串扰的创新平台。灵活的探针设计、粘附配体的特异性以及刺激条件的精确调节,可以对EGFR-整合素相互作用进行可靠的定量评估。结果突出了EGFR作为“机械组织者”调谐整合机制,影响焦点粘附组装和细胞扩散。

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