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A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus
JoVE Journal
Neurociência
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JoVE Journal Neurociência
A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus

A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus

DOI:
10.3791/63673-v

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05:33 min

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June 23, 2022

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, , , , ,
1Department of Pharmacology and Toxicology,University of Utah, 2Interdepartmental Program in Neuroscience,University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology,Freie Universität Berlin

Capítulos

  • 00:05Introduction
  • 00:56Virus Inoculation
  • 02:45Seizure Monitoring of Handling‐Induced Seizures
  • 03:29Results: Infection‐Based Rodent Model for Epilepsy to Investigate Acute and Chronic Seizure Development
  • 04:41Conclusion

Summary

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Intracerebral infection with the Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6 mice replicates many of the early and chronic clinical symptoms of viral encephalitis and subsequent epilepsy in human patients. This paper describes the virus infection, symptoms, and histopathology of the TMEV model.

Tags

Keywords: TMEV ModelEpilepsyCNS InfectionExperimental ModelVirus InjectionTheiler’s Murine Encephalomyelitis VirusSeizure DevelopmentTherapeutic TargetsGraduate StudentInjection ProcedureAnesthesiaIntracordical InjectionSeizure ActivityModified Racine Scale

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