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使用交流介电泳分离非转移性（MCF-7）和非肿瘤（MCF-10A）乳腺癌细胞的微流体装置

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Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis

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使用交流介电泳分离非转移性（MCF-7）和非肿瘤（MCF-10A）乳腺癌细胞的微流体装置

DOI:

10.3791/63850-v

•

08:33 min

•

August 11, 2022

•

Ateeq ur Rehman, Rahman S. Zabibah, Samira Kharratian, Adil Mustafa⁵

¹Department of Biomedical Engineering,Foundation University Islamabad, ²College of Medical Technology,The Islamic University Najaf, ³Faculty of Mechanical Engineering,University of Tabriz, ⁴Department of Engineering Mathematics,University of Bristol, ⁵School of Life Sciences,University of Warwick

Capítulos

00:05Introduction
00:43Chip Design and Parameter Selection
04:01Mathematical Model and Computational Analysis
05:59Results: Investigating the Optimal Operational Parameters for Effective DEP-Based Sorting
07:59Conclusion

Summary

Tadução automática

与非肿瘤乳腺上皮细胞相比，乳腺癌细胞表现出不同的介电特性。据推测，基于介电特性的这种差异，可以出于免疫治疗目的将两个群体分开。为了支持这一点，我们模拟了一种微流体装置来分选MCF-7和MCF-10A细胞。

Tags

Microfluidic Device AC Dielectrophoresis Non-metastatic Breast Cancer Cells Non-tumor Breast Epithelial Cells Cell Separation Dielectric Properties Multiphysics Simulation Particle Tracing Fluid Flow Electric Field

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