Journal
/
Química
/
使用系绳上的锍中心构建环肽
JoVE Journal
Química
É necessária uma assinatura da JoVE para visualizar este conteúdo.  Faça login ou comece sua avaliação gratuita.
JoVE Journal Química
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Please note that all translations are automatically generated. Click here for the English version.

使用系绳上的锍中心构建环肽

DOI:
10.3791/64289-v

•

07:11 min

•

September 28, 2022

•

, , , , , , , ,
1Pingshan Translational Medicine Center,Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital,Anhui Medical University

Capítulos

  • 00:04Introduction
  • 00:38N-Terminal Fmoc Deprotection
  • 01:36Coupling the Linear Peptide
  • 02:49Bisalkylation Between Methionine and Cysteine
  • 04:34Propargyl Sulfonium Salt Cyclization
  • 05:21Results: Characterization of the Synthesized Peptides
  • 06:32Conclusion

Summary

Tadução automática

Tadução automática

该协议介绍了通过半胱氨酸和蛋氨酸之间的双烷基化以及由炔丙基锍中心触发的简单硫醇 - 炔反应 合成 环肽。

Tags

Cyclic PeptideSulfonium CenterCysteineN-terminal DeprotectionPeptide CouplingNinhydrin TestResin WashingTrityl-L-cysteine Deprotection

Article

Embed

ADICIONAR À PLAYLIST

Usage Statistics

Vídeos Relacionados

保利的微波辅助功能化（乙二醇）和On-树脂链聚合反应，并形成水凝胶的肽使用

生物分子有序结构由短肽的自组装形成

一个主干环肽库作为潜在的抗寄生虫治疗微波辐射的发展

环状聚合物的合成及其在熔融状态扩散运动的表征在单分子水平

洞察氨基酸和多肽与无机材料的使用相互作用的单分子力谱

利用 iccd 摄像机对无氧环境下的三重收集有机化合物进行光物理表征

利用循环伏安法、紫外-近红外光谱和 EPR 光谱电化学对有机化合物进行分析

利用光致硫醇-烯/yne Hydrothiolation 构造硫醚类/乙烯基硫化物栓系螺旋肽

12-Dithiolane 改性自组装肽的合成与表征

药物药代动力学和毒理学评估的肠道/肝脏微生理系统

Read Article