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Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
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JoVE Journal Bioengenharia
Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

DOI:
10.3791/64432-v

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08:17 min

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April 14, 2023

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, , , , , , ,
1Thoracic Surgery Department,Hospital Universitari de la Ribera, 2Pathology Department,Universitat de Valencia Facultat de Medicina i Odontologia, 3Center for Biomaterials and Tissue Engineering,Universitat Politècnica de València, 4Radiation Oncology,Hospital Universitari de la Ribera, 5Thoracic Surgery Department,Hospitales Universitarios Virgen del Rocío, 6Department of Applied Statistics and Operations Research and Quality,Universitat Politècnica de València, 7Networking Research Center on Respiratory Diseases (CIBERER), 8INCLIVA Biomedical Research Institute

Capítulos

  • 00:05Introduction
  • 00:59Tracheal Decellularization
  • 02:08Sterilization
  • 03:09Biomechanical Study
  • 05:13Surgical Technique
  • 06:03Results: Effect of an Escalated Radiation Dose in a Decellularized Rabbit Trachea
  • 07:37Conclusion

Summary

Tadução automática

Tadução automática

Obtaining sterilization is essential for tracheal tissue transplant. Herein, we present a sterilization protocol using low-dose gamma irradiation that is fully tolerated by organs.

Tags

Gamma RadiationSterilizationDecellularized Tracheal GraftsLow-doseOrgan SterilizationBiological MaterialsTensile TestsUniversal Testing Machine

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