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Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects
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JoVE Journal Medicina
Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects

Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects

DOI:
10.3791/64475-v

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04:34 min

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May 19, 2023

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, , , , , , , , , ,
1The First Affiliated Hospital,Zhejiang Chinese Medical University, 2Fuyang Orthopaedics and Traumatology Affiliated Hospital,Zhejiang Chinese Medical University, 3College of Pharmaceutical Science,Zhejiang Chinese Medical University, 4Affiliated Zhejiang Hospital,Zhejiang University School of Medicine, 5Xianju County Hospital of Chinese Medicine

Capítulos

  • 00:04Introduction
  • 01:18Establishment of Murine Full‐Thickness Cartilage Defects Model
  • 02:27Measurement of Mechanical Withdrawal Threshold
  • 03:12Results: Comparative Analysis of Mechanical Withdrawal Threshold in Murine Models
  • 04:10Conclusion

Summary

Tadução automática

Tadução automática

This protocol establishes a full-thickness cartilage defects (FTCD) model by drilling holes in the femoral trochlear groove of rats and measuring the subsequent pain behavior and histopathological changes.

Tags

Rat ModelFull-thickness Cartilage DefectsFTCDTraumatic Cartilage DefectsPost-traumatic OsteoarthritisCartilage InjuryAnimal ModelCartilage Defect EvaluationMechanical Withdrawal ThresholdHyperalgesia

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