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Ipertermia generata da ultrasuoni focalizzati ad alta intensità guidata da risonanza magnetica: un metodo di trattamento fattibile in un modello di rabdomiosarcoma murino
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1Institute of Medical Science,University of Toronto, 2Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital, 3The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention,The Hospital for Sick Children, 4Institute of Biomedical Engineering,University of Toronto, 5Leslie Dan Faculty of Pharmacy,University of Toronto, 6Departments of Radiology and Clinical Neurosciences,University of Calgary, 7Department of Radiation Oncology,University of Toronto, 8Department of Medical Imaging,University of Toronto, 9Department of Pediatric Surgery,University of Toronto, 10Department of Surgery,University of Toronto
Capítulos
- 00:04Introduction
- 01:11Intramuscular Cell Injection
- 02:08Screening MRI Scan and HIFU Treatment
- 10:46Results: Average Temperatures and Success Rates of Hyperthermia Treatment and Doxorubicin Levels in the Tumor
- 13:03Conclusion
Presentato qui è un protocollo per utilizzare l'ipertermia controllata, generata da ultrasuoni focalizzati ad alta intensità guidati da risonanza magnetica, per innescare il rilascio di farmaci da liposomi sensibili alla temperatura in un modello murino di rabdomiosarcoma.
