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JoVE Journal Cancer Research
Toepassing van AlDeSense om eierstokkankercellen te stratificeren op basis van aldehydedehydrogenase 1A1-activiteit
 
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Toepassing van AlDeSense om eierstokkankercellen te stratificeren op basis van aldehydedehydrogenase 1A1-activiteit

Article DOI: 10.3791/64713-v • 09:59 min • March 31st, 2023
March 31st, 2023 •
*1,3,4, *2,3,4, 1,3,4, 1,2,3,4
1Department of Chemistry, University of Illinois Urbana-Champaign, 2Department of Biochemistry, University of Illinois Urbana-Champaign, 3Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, 4Cancer Center of Illinois, University of Illinois Urbana-Champaign
* These authors contributed equally

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Methoden om ALDH1A1-activiteit in levende cellen te meten zijn van cruciaal belang in kankeronderzoek vanwege de status als biomarker van stam. In deze studie gebruikten we een isovormselectieve fluorogene sonde om de relatieve niveaus van ALDH1A1-activiteit te bepalen in een panel van vijf eierstokkankercellijnen.

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Deze maand in JoVE nummer 193
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